APRIL // GATE

Sources

Primary references for every figure, claim, and statistic April Gate cites in its product, pitch materials, and public communications.

Last updated: May 2026

01 · The $35 Billion Loss

"The biopharma industry loses approximately $35 billion annually as a result of failures in temperature-controlled logistics."

IQVIA Institute for Human Data Science — 2019 Biopharma Cold Chain Logistics Survey
Published by Pelican BioThermal. Includes lost product, clinical trial loss and replacement costs, wasted logistics costs, and root-cause analysis costs.
cdn2.hubspot.net/.../PEL1046_SurveyReport_v4a.pdf
Air Cargo News — July 2019
"Failures in temperature-controlled logistics cost biopharma industry billions." Trade-press coverage of the IQVIA figure.
aircargonews.net/sectors/pharma-logistics/failures-in-temperature-controlled-logistics
Note on scope. The $35B figure is biopharma-specific, not all cold chain. Other industry sources give a range of $20B–$35B.

02 · Vaccine Wastage

"More than 50% of vaccines may be wasted globally every year, in part due to temperature control, logistics, and shipment-related issues."

World Health Organization
Original WHO publication (2005), reiterated across subsequent Effective Vaccine Management (EVM) materials and WHO immunization supply chain documentation.
who.int/teams/immunization-vaccines-and-biologicals/.../supply-chain
UN Environment Programme — June 2020
"Why optimized cold-chains could save a billion COVID vaccines." Quantifies the WHO figure at COVID-rollout scale.
unep.org/news-and-stories/story/why-optimized-cold-chains-could-save-billion-covid-vaccines
World Economic Forum — 2018
"Over half of vaccines are wasted globally for these simple reasons."
weforum.org/stories/2018/07/the-biggest-hurdle-to-universal-vaccination-might-just-be-a-fridge

03 · Temperature Excursion Rates

"Approximately 12% of pharmaceutical shipments still experience temperature excursions, with up to 50% of vaccines compromised each year."

The Medicine Maker — April 2026
"A Reliable Cold Chain is a Health Equity Issue." Recent industry analysis of excursion rates and downstream consequences.
themedicinemaker.com/issues/2026/articles/april/a-reliable-cold-chain-is-a-health-equity-issue

04 · Market Size & Growth

"The global pharma cold chain logistics market is projected at $27.7B by 2028 (5.26% CAGR); the broader cold chain market grows from $436B (2025) to $1.36T by 2034."

Pharmaceutical Commerce — March 2026
"The Pharma Cold Chain: More Visible, More Sustainable—and Colder." Citing IQVIA Global Use of Medicines 2024, Visiongain, ResearchAndMarkets, Emergen Research.
pharmaceuticalcommerce.com/view/the-pharma-cold-chain-more-visible-more-sustainable-and-colder
CCP Logistics — March 2026
"Cold Chain Logistics in 2026: Precision, Protection and Performance." Broader cold chain market forecast through 2034.
ccplogistics.com/cold-chain-logistics-in-2026-precision-protection-and-performance

05 · Dispute Resolution & Claims Process

"Temperature excursion claims today are adjudicated through manual data-logger downloads and document review. Carriers publish multi-week SLAs for resolution; full insurance and legal disputes routinely extend further."

LATAM Cargo — Pharma Service SLAs
Published resolution timeline: 12 business days (Passive Pharma) / 18 business days (Active Pharma) for temperature excursion claim investigation.
latamcargo.com/en/pharma
Eupry — Pharmaceutical Air Freight Temperature Monitoring Guide
On root-cause attribution gaps across multi-party handoffs: gaps in temperature records make responsibility assignment under freight contracts difficult.
eupry.com/temperature-monitoring/air-cargo-monitoring
Marlin Blue — April 2025
"What to do when facing a cargo damage claim." On legal advisor involvement in complex, high-value, or disputed claims.
marlinblue.com/cargo-damage-claim-guide

06 · Regulatory Framework

"April Gate's attestation outputs are designed to be compatible with the documentation and traceability requirements of EU GDP, US DSCSA, and IATA TCR."

European Commission — EU Good Distribution Practice
Guidelines on Good Distribution Practice of medicinal products for human use (2013/C 343/01).
health.ec.europa.eu/medicinal-products/eudralex/eudralex-volume-4_en
US Food and Drug Administration — Drug Supply Chain Security Act
DSCSA traceability and documentation requirements for the pharmaceutical supply chain.
fda.gov/drugs/drug-supply-chain-integrity/drug-supply-chain-security-act-dscsa
IATA — Temperature Control Regulations
Best practices for air freight of temperature-sensitive pharmaceuticals.
iata.org/en/publications/store/temperature-control-regulations